indole 3 propionic acid Search Results


v9302  (MedChemExpress)
94
MedChemExpress v9302
A – C The expression of Asct2 and Gls1 at the mRNA and protein level on day 1, 3, and 5 during OC differentiation. Statistical significance: * p < 0.05, ** p < 0.01, *** p < 0.001; ns, no significance. D , E Glu regulate RANKL-induced osteoclastogenesis in a concentration-dependent manner. BMDMs were treated with different concentrations of Glu (0 mM,0.5 mM, 1 mM, 2 mM and 4 mM) or 5 μM <t>V9302</t> for 5 days. TRAP-positive multinucleated (>3 nuclei) cells were counted as osteoclasts. * p < 0.05, ** p < 0.01, *** p < 0.001. F , G BMDMs were seeded on 0.2% collagen-gel-coated 6-well plates and stimulated with 30 ng/ml M- CSF and 75 ng/ml RANKL for 6 days. Then, the cells were digested and seeded onto the Osteo Assay stripwell plates. Mature osteoclasts were treated with various concentrations of Glu or 5 μM V9302 for 5 days. F-actin staining was then performed. * p < 0.05, ** p < 0.01, *** p < 0.001. H , I Pit formation assay in the Glu (0 mM,0.5 mM, 1 mM, 2 mM and 4 mM) or 5 μM V9302 treated group. Mature osteoclasts were cultured on Osteo Assay stripwell plates and treated with the medium containing RANKL and various concentrations of Glu for 2 days. The cells were then washed from the surface by using the 10% bleaching solution for 5 min. Resorption pits were captured with light microscopy and analyzed with Image J software. * p < 0.05, ** p < 0.01, *** p < 0.001. J – M BMDMs were cultured with the medium containing M- CSF, RANKL and various concentrations of Glu or were treated by 5 μM V9302 for 5 days. Relative mRNA expression levels of Nfatc1, Mmp9, Ctsk, and Acp5 versus β-Actin were quantified by qPCR. *compared to Glu (0 mM)/V9302 (0 μM) group; #compare to Glu (2 mM)/V9302(0 μM) group; * p < 0.05, ** p < 0.01, *** p < 0.001. # p < 0.05, ## p < 0.01, ### p < 0.001.
V9302, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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5 methoxy l tryptophan 16 s  (Chem Impex International)
95
Chem Impex International 5 methoxy l tryptophan 16 s
A – C The expression of Asct2 and Gls1 at the mRNA and protein level on day 1, 3, and 5 during OC differentiation. Statistical significance: * p < 0.05, ** p < 0.01, *** p < 0.001; ns, no significance. D , E Glu regulate RANKL-induced osteoclastogenesis in a concentration-dependent manner. BMDMs were treated with different concentrations of Glu (0 mM,0.5 mM, 1 mM, 2 mM and 4 mM) or 5 μM <t>V9302</t> for 5 days. TRAP-positive multinucleated (>3 nuclei) cells were counted as osteoclasts. * p < 0.05, ** p < 0.01, *** p < 0.001. F , G BMDMs were seeded on 0.2% collagen-gel-coated 6-well plates and stimulated with 30 ng/ml M- CSF and 75 ng/ml RANKL for 6 days. Then, the cells were digested and seeded onto the Osteo Assay stripwell plates. Mature osteoclasts were treated with various concentrations of Glu or 5 μM V9302 for 5 days. F-actin staining was then performed. * p < 0.05, ** p < 0.01, *** p < 0.001. H , I Pit formation assay in the Glu (0 mM,0.5 mM, 1 mM, 2 mM and 4 mM) or 5 μM V9302 treated group. Mature osteoclasts were cultured on Osteo Assay stripwell plates and treated with the medium containing RANKL and various concentrations of Glu for 2 days. The cells were then washed from the surface by using the 10% bleaching solution for 5 min. Resorption pits were captured with light microscopy and analyzed with Image J software. * p < 0.05, ** p < 0.01, *** p < 0.001. J – M BMDMs were cultured with the medium containing M- CSF, RANKL and various concentrations of Glu or were treated by 5 μM V9302 for 5 days. Relative mRNA expression levels of Nfatc1, Mmp9, Ctsk, and Acp5 versus β-Actin were quantified by qPCR. *compared to Glu (0 mM)/V9302 (0 μM) group; #compare to Glu (2 mM)/V9302(0 μM) group; * p < 0.05, ** p < 0.01, *** p < 0.001. # p < 0.05, ## p < 0.01, ### p < 0.001.
5 Methoxy L Tryptophan 16 S, supplied by Chem Impex International, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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3 indole propionic acid  (Valiant Co Ltd)
92
Valiant Co Ltd 3 indole propionic acid
A – C The expression of Asct2 and Gls1 at the mRNA and protein level on day 1, 3, and 5 during OC differentiation. Statistical significance: * p < 0.05, ** p < 0.01, *** p < 0.001; ns, no significance. D , E Glu regulate RANKL-induced osteoclastogenesis in a concentration-dependent manner. BMDMs were treated with different concentrations of Glu (0 mM,0.5 mM, 1 mM, 2 mM and 4 mM) or 5 μM <t>V9302</t> for 5 days. TRAP-positive multinucleated (>3 nuclei) cells were counted as osteoclasts. * p < 0.05, ** p < 0.01, *** p < 0.001. F , G BMDMs were seeded on 0.2% collagen-gel-coated 6-well plates and stimulated with 30 ng/ml M- CSF and 75 ng/ml RANKL for 6 days. Then, the cells were digested and seeded onto the Osteo Assay stripwell plates. Mature osteoclasts were treated with various concentrations of Glu or 5 μM V9302 for 5 days. F-actin staining was then performed. * p < 0.05, ** p < 0.01, *** p < 0.001. H , I Pit formation assay in the Glu (0 mM,0.5 mM, 1 mM, 2 mM and 4 mM) or 5 μM V9302 treated group. Mature osteoclasts were cultured on Osteo Assay stripwell plates and treated with the medium containing RANKL and various concentrations of Glu for 2 days. The cells were then washed from the surface by using the 10% bleaching solution for 5 min. Resorption pits were captured with light microscopy and analyzed with Image J software. * p < 0.05, ** p < 0.01, *** p < 0.001. J – M BMDMs were cultured with the medium containing M- CSF, RANKL and various concentrations of Glu or were treated by 5 μM V9302 for 5 days. Relative mRNA expression levels of Nfatc1, Mmp9, Ctsk, and Acp5 versus β-Actin were quantified by qPCR. *compared to Glu (0 mM)/V9302 (0 μM) group; #compare to Glu (2 mM)/V9302(0 μM) group; * p < 0.05, ** p < 0.01, *** p < 0.001. # p < 0.05, ## p < 0.01, ### p < 0.001.
3 Indole Propionic Acid, supplied by Valiant Co Ltd, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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indole 3 propionic acid  (Chem Impex International)
95
Chem Impex International indole 3 propionic acid
A – C The expression of Asct2 and Gls1 at the mRNA and protein level on day 1, 3, and 5 during OC differentiation. Statistical significance: * p < 0.05, ** p < 0.01, *** p < 0.001; ns, no significance. D , E Glu regulate RANKL-induced osteoclastogenesis in a concentration-dependent manner. BMDMs were treated with different concentrations of Glu (0 mM,0.5 mM, 1 mM, 2 mM and 4 mM) or 5 μM <t>V9302</t> for 5 days. TRAP-positive multinucleated (>3 nuclei) cells were counted as osteoclasts. * p < 0.05, ** p < 0.01, *** p < 0.001. F , G BMDMs were seeded on 0.2% collagen-gel-coated 6-well plates and stimulated with 30 ng/ml M- CSF and 75 ng/ml RANKL for 6 days. Then, the cells were digested and seeded onto the Osteo Assay stripwell plates. Mature osteoclasts were treated with various concentrations of Glu or 5 μM V9302 for 5 days. F-actin staining was then performed. * p < 0.05, ** p < 0.01, *** p < 0.001. H , I Pit formation assay in the Glu (0 mM,0.5 mM, 1 mM, 2 mM and 4 mM) or 5 μM V9302 treated group. Mature osteoclasts were cultured on Osteo Assay stripwell plates and treated with the medium containing RANKL and various concentrations of Glu for 2 days. The cells were then washed from the surface by using the 10% bleaching solution for 5 min. Resorption pits were captured with light microscopy and analyzed with Image J software. * p < 0.05, ** p < 0.01, *** p < 0.001. J – M BMDMs were cultured with the medium containing M- CSF, RANKL and various concentrations of Glu or were treated by 5 μM V9302 for 5 days. Relative mRNA expression levels of Nfatc1, Mmp9, Ctsk, and Acp5 versus β-Actin were quantified by qPCR. *compared to Glu (0 mM)/V9302 (0 μM) group; #compare to Glu (2 mM)/V9302(0 μM) group; * p < 0.05, ** p < 0.01, *** p < 0.001. # p < 0.05, ## p < 0.01, ### p < 0.001.
Indole 3 Propionic Acid, supplied by Chem Impex International, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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nα fmoc nin methyl l tryptophan  (Chem Impex International)
95
Chem Impex International nα fmoc nin methyl l tryptophan
A – C The expression of Asct2 and Gls1 at the mRNA and protein level on day 1, 3, and 5 during OC differentiation. Statistical significance: * p < 0.05, ** p < 0.01, *** p < 0.001; ns, no significance. D , E Glu regulate RANKL-induced osteoclastogenesis in a concentration-dependent manner. BMDMs were treated with different concentrations of Glu (0 mM,0.5 mM, 1 mM, 2 mM and 4 mM) or 5 μM <t>V9302</t> for 5 days. TRAP-positive multinucleated (>3 nuclei) cells were counted as osteoclasts. * p < 0.05, ** p < 0.01, *** p < 0.001. F , G BMDMs were seeded on 0.2% collagen-gel-coated 6-well plates and stimulated with 30 ng/ml M- CSF and 75 ng/ml RANKL for 6 days. Then, the cells were digested and seeded onto the Osteo Assay stripwell plates. Mature osteoclasts were treated with various concentrations of Glu or 5 μM V9302 for 5 days. F-actin staining was then performed. * p < 0.05, ** p < 0.01, *** p < 0.001. H , I Pit formation assay in the Glu (0 mM,0.5 mM, 1 mM, 2 mM and 4 mM) or 5 μM V9302 treated group. Mature osteoclasts were cultured on Osteo Assay stripwell plates and treated with the medium containing RANKL and various concentrations of Glu for 2 days. The cells were then washed from the surface by using the 10% bleaching solution for 5 min. Resorption pits were captured with light microscopy and analyzed with Image J software. * p < 0.05, ** p < 0.01, *** p < 0.001. J – M BMDMs were cultured with the medium containing M- CSF, RANKL and various concentrations of Glu or were treated by 5 μM V9302 for 5 days. Relative mRNA expression levels of Nfatc1, Mmp9, Ctsk, and Acp5 versus β-Actin were quantified by qPCR. *compared to Glu (0 mM)/V9302 (0 μM) group; #compare to Glu (2 mM)/V9302(0 μM) group; * p < 0.05, ** p < 0.01, *** p < 0.001. # p < 0.05, ## p < 0.01, ### p < 0.001.
Nα Fmoc Nin Methyl L Tryptophan, supplied by Chem Impex International, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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lc ms standard  (Chem Impex International)
95
Chem Impex International lc ms standard
A – C The expression of Asct2 and Gls1 at the mRNA and protein level on day 1, 3, and 5 during OC differentiation. Statistical significance: * p < 0.05, ** p < 0.01, *** p < 0.001; ns, no significance. D , E Glu regulate RANKL-induced osteoclastogenesis in a concentration-dependent manner. BMDMs were treated with different concentrations of Glu (0 mM,0.5 mM, 1 mM, 2 mM and 4 mM) or 5 μM <t>V9302</t> for 5 days. TRAP-positive multinucleated (>3 nuclei) cells were counted as osteoclasts. * p < 0.05, ** p < 0.01, *** p < 0.001. F , G BMDMs were seeded on 0.2% collagen-gel-coated 6-well plates and stimulated with 30 ng/ml M- CSF and 75 ng/ml RANKL for 6 days. Then, the cells were digested and seeded onto the Osteo Assay stripwell plates. Mature osteoclasts were treated with various concentrations of Glu or 5 μM V9302 for 5 days. F-actin staining was then performed. * p < 0.05, ** p < 0.01, *** p < 0.001. H , I Pit formation assay in the Glu (0 mM,0.5 mM, 1 mM, 2 mM and 4 mM) or 5 μM V9302 treated group. Mature osteoclasts were cultured on Osteo Assay stripwell plates and treated with the medium containing RANKL and various concentrations of Glu for 2 days. The cells were then washed from the surface by using the 10% bleaching solution for 5 min. Resorption pits were captured with light microscopy and analyzed with Image J software. * p < 0.05, ** p < 0.01, *** p < 0.001. J – M BMDMs were cultured with the medium containing M- CSF, RANKL and various concentrations of Glu or were treated by 5 μM V9302 for 5 days. Relative mRNA expression levels of Nfatc1, Mmp9, Ctsk, and Acp5 versus β-Actin were quantified by qPCR. *compared to Glu (0 mM)/V9302 (0 μM) group; #compare to Glu (2 mM)/V9302(0 μM) group; * p < 0.05, ** p < 0.01, *** p < 0.001. # p < 0.05, ## p < 0.01, ### p < 0.001.
Lc Ms Standard, supplied by Chem Impex International, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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resource source identifier l tryptophan sigma aldrich cat  (ChromaDex)
90
ChromaDex resource source identifier l tryptophan sigma aldrich cat
A – C The expression of Asct2 and Gls1 at the mRNA and protein level on day 1, 3, and 5 during OC differentiation. Statistical significance: * p < 0.05, ** p < 0.01, *** p < 0.001; ns, no significance. D , E Glu regulate RANKL-induced osteoclastogenesis in a concentration-dependent manner. BMDMs were treated with different concentrations of Glu (0 mM,0.5 mM, 1 mM, 2 mM and 4 mM) or 5 μM <t>V9302</t> for 5 days. TRAP-positive multinucleated (>3 nuclei) cells were counted as osteoclasts. * p < 0.05, ** p < 0.01, *** p < 0.001. F , G BMDMs were seeded on 0.2% collagen-gel-coated 6-well plates and stimulated with 30 ng/ml M- CSF and 75 ng/ml RANKL for 6 days. Then, the cells were digested and seeded onto the Osteo Assay stripwell plates. Mature osteoclasts were treated with various concentrations of Glu or 5 μM V9302 for 5 days. F-actin staining was then performed. * p < 0.05, ** p < 0.01, *** p < 0.001. H , I Pit formation assay in the Glu (0 mM,0.5 mM, 1 mM, 2 mM and 4 mM) or 5 μM V9302 treated group. Mature osteoclasts were cultured on Osteo Assay stripwell plates and treated with the medium containing RANKL and various concentrations of Glu for 2 days. The cells were then washed from the surface by using the 10% bleaching solution for 5 min. Resorption pits were captured with light microscopy and analyzed with Image J software. * p < 0.05, ** p < 0.01, *** p < 0.001. J – M BMDMs were cultured with the medium containing M- CSF, RANKL and various concentrations of Glu or were treated by 5 μM V9302 for 5 days. Relative mRNA expression levels of Nfatc1, Mmp9, Ctsk, and Acp5 versus β-Actin were quantified by qPCR. *compared to Glu (0 mM)/V9302 (0 μM) group; #compare to Glu (2 mM)/V9302(0 μM) group; * p < 0.05, ** p < 0.01, *** p < 0.001. # p < 0.05, ## p < 0.01, ### p < 0.001.
Resource Source Identifier L Tryptophan Sigma Aldrich Cat, supplied by ChromaDex, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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3h]2-carboxy-4,6-dichloro-1h-indole-3-propionic acid ([3h]psb-12150)  (CNS Research)
90
CNS Research 3h]2-carboxy-4,6-dichloro-1h-indole-3-propionic acid ([3h]psb-12150)
A – C The expression of Asct2 and Gls1 at the mRNA and protein level on day 1, 3, and 5 during OC differentiation. Statistical significance: * p < 0.05, ** p < 0.01, *** p < 0.001; ns, no significance. D , E Glu regulate RANKL-induced osteoclastogenesis in a concentration-dependent manner. BMDMs were treated with different concentrations of Glu (0 mM,0.5 mM, 1 mM, 2 mM and 4 mM) or 5 μM <t>V9302</t> for 5 days. TRAP-positive multinucleated (>3 nuclei) cells were counted as osteoclasts. * p < 0.05, ** p < 0.01, *** p < 0.001. F , G BMDMs were seeded on 0.2% collagen-gel-coated 6-well plates and stimulated with 30 ng/ml M- CSF and 75 ng/ml RANKL for 6 days. Then, the cells were digested and seeded onto the Osteo Assay stripwell plates. Mature osteoclasts were treated with various concentrations of Glu or 5 μM V9302 for 5 days. F-actin staining was then performed. * p < 0.05, ** p < 0.01, *** p < 0.001. H , I Pit formation assay in the Glu (0 mM,0.5 mM, 1 mM, 2 mM and 4 mM) or 5 μM V9302 treated group. Mature osteoclasts were cultured on Osteo Assay stripwell plates and treated with the medium containing RANKL and various concentrations of Glu for 2 days. The cells were then washed from the surface by using the 10% bleaching solution for 5 min. Resorption pits were captured with light microscopy and analyzed with Image J software. * p < 0.05, ** p < 0.01, *** p < 0.001. J – M BMDMs were cultured with the medium containing M- CSF, RANKL and various concentrations of Glu or were treated by 5 μM V9302 for 5 days. Relative mRNA expression levels of Nfatc1, Mmp9, Ctsk, and Acp5 versus β-Actin were quantified by qPCR. *compared to Glu (0 mM)/V9302 (0 μM) group; #compare to Glu (2 mM)/V9302(0 μM) group; * p < 0.05, ** p < 0.01, *** p < 0.001. # p < 0.05, ## p < 0.01, ### p < 0.001.
3h]2 Carboxy 4,6 Dichloro 1h Indole 3 Propionic Acid ([3h]Psb 12150), supplied by CNS Research, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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d2-indole-3-propionic acid  (Toronto Research Chemicals)
90
Toronto Research Chemicals d2-indole-3-propionic acid
A – C The expression of Asct2 and Gls1 at the mRNA and protein level on day 1, 3, and 5 during OC differentiation. Statistical significance: * p < 0.05, ** p < 0.01, *** p < 0.001; ns, no significance. D , E Glu regulate RANKL-induced osteoclastogenesis in a concentration-dependent manner. BMDMs were treated with different concentrations of Glu (0 mM,0.5 mM, 1 mM, 2 mM and 4 mM) or 5 μM <t>V9302</t> for 5 days. TRAP-positive multinucleated (>3 nuclei) cells were counted as osteoclasts. * p < 0.05, ** p < 0.01, *** p < 0.001. F , G BMDMs were seeded on 0.2% collagen-gel-coated 6-well plates and stimulated with 30 ng/ml M- CSF and 75 ng/ml RANKL for 6 days. Then, the cells were digested and seeded onto the Osteo Assay stripwell plates. Mature osteoclasts were treated with various concentrations of Glu or 5 μM V9302 for 5 days. F-actin staining was then performed. * p < 0.05, ** p < 0.01, *** p < 0.001. H , I Pit formation assay in the Glu (0 mM,0.5 mM, 1 mM, 2 mM and 4 mM) or 5 μM V9302 treated group. Mature osteoclasts were cultured on Osteo Assay stripwell plates and treated with the medium containing RANKL and various concentrations of Glu for 2 days. The cells were then washed from the surface by using the 10% bleaching solution for 5 min. Resorption pits were captured with light microscopy and analyzed with Image J software. * p < 0.05, ** p < 0.01, *** p < 0.001. J – M BMDMs were cultured with the medium containing M- CSF, RANKL and various concentrations of Glu or were treated by 5 μM V9302 for 5 days. Relative mRNA expression levels of Nfatc1, Mmp9, Ctsk, and Acp5 versus β-Actin were quantified by qPCR. *compared to Glu (0 mM)/V9302 (0 μM) group; #compare to Glu (2 mM)/V9302(0 μM) group; * p < 0.05, ** p < 0.01, *** p < 0.001. # p < 0.05, ## p < 0.01, ### p < 0.001.
D2 Indole 3 Propionic Acid, supplied by Toronto Research Chemicals, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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indole-3-propionic acid ipa  (Merck KGaA)
90
Merck KGaA indole-3-propionic acid ipa
A – C The expression of Asct2 and Gls1 at the mRNA and protein level on day 1, 3, and 5 during OC differentiation. Statistical significance: * p < 0.05, ** p < 0.01, *** p < 0.001; ns, no significance. D , E Glu regulate RANKL-induced osteoclastogenesis in a concentration-dependent manner. BMDMs were treated with different concentrations of Glu (0 mM,0.5 mM, 1 mM, 2 mM and 4 mM) or 5 μM <t>V9302</t> for 5 days. TRAP-positive multinucleated (>3 nuclei) cells were counted as osteoclasts. * p < 0.05, ** p < 0.01, *** p < 0.001. F , G BMDMs were seeded on 0.2% collagen-gel-coated 6-well plates and stimulated with 30 ng/ml M- CSF and 75 ng/ml RANKL for 6 days. Then, the cells were digested and seeded onto the Osteo Assay stripwell plates. Mature osteoclasts were treated with various concentrations of Glu or 5 μM V9302 for 5 days. F-actin staining was then performed. * p < 0.05, ** p < 0.01, *** p < 0.001. H , I Pit formation assay in the Glu (0 mM,0.5 mM, 1 mM, 2 mM and 4 mM) or 5 μM V9302 treated group. Mature osteoclasts were cultured on Osteo Assay stripwell plates and treated with the medium containing RANKL and various concentrations of Glu for 2 days. The cells were then washed from the surface by using the 10% bleaching solution for 5 min. Resorption pits were captured with light microscopy and analyzed with Image J software. * p < 0.05, ** p < 0.01, *** p < 0.001. J – M BMDMs were cultured with the medium containing M- CSF, RANKL and various concentrations of Glu or were treated by 5 μM V9302 for 5 days. Relative mRNA expression levels of Nfatc1, Mmp9, Ctsk, and Acp5 versus β-Actin were quantified by qPCR. *compared to Glu (0 mM)/V9302 (0 μM) group; #compare to Glu (2 mM)/V9302(0 μM) group; * p < 0.05, ** p < 0.01, *** p < 0.001. # p < 0.05, ## p < 0.01, ### p < 0.001.
Indole 3 Propionic Acid Ipa, supplied by Merck KGaA, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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indole-3-propionic-2,2-d2 acid  (Cambridge Isotope Laboratories)
90
Cambridge Isotope Laboratories indole-3-propionic-2,2-d2 acid
a Variable importance plot of top 50 fecal metabolites ( y -axis) ranked by contribution to mean decrease accuracy of Gini coefficient ( x -axis) in the random forest model for discerning group difference. b Diagram summary of perturbed fecal pathways of phenylalanine, tyrosine, and tryptophan biosynthesis and metabolism, with significantly altered metabolites labeled in red (GF>CONV-R) or blue (GF<CONV-R) (two-sided Welch’s t -test, fold change ≥ 1.5, p < 0.01). c, d Box and Whisker plots of fecal indoles ( c ) and bile acid profiles ( d ) as synthesized or mediated by microbiota, with the box ranging from the first quartile to the third while the whiskers going from each quartile to the minimum or maximum (GF, N = 12; CONV-R, N = 12), * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001, two-sided Welch’s t -test; exact p values and adjusted p values (i.e., q values) are provided in Supplementary Data . SM sphingomyelin, Phe L-phenylalanine, Tyr L-tyrosine, Trp L-tryptophan, 5-HT 5-hydroxytryptamine, NAS N-acetylserotonin, 5-MIAA 5-methoxyindole-3-acetate, Kyna kynurenate, Kyn L-kynurenine, AA anthranilate, XA xanthurenate, IAA <t>indole-3-acetate,</t> IPA indole-3-propionate, ILA indole-3-lactate, I3A indole-3-carboxaldehyde, L-DOPA L-3,4-dihydroxyphenylalanine, DHICA 5,6-dihydroxyindole-2-carboxylate, CDCA chenodeoxycholate, CA cholate, αMCA α-muricholate, TCDCA taurochenodeoxycholate, TCA taurocholate, TαMCA tauro α-muricholate, DCA deoxycholate, HDCA hyodeoxycholate, LCA lithocholate.
Indole 3 Propionic 2,2 D2 Acid, supplied by Cambridge Isotope Laboratories, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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labeled internal standard indole-3-propionic-2,2-d 2 acid no. d-7686  (CDN Isotopes)
90
CDN Isotopes labeled internal standard indole-3-propionic-2,2-d 2 acid no. d-7686
a Variable importance plot of top 50 fecal metabolites ( y -axis) ranked by contribution to mean decrease accuracy of Gini coefficient ( x -axis) in the random forest model for discerning group difference. b Diagram summary of perturbed fecal pathways of phenylalanine, tyrosine, and tryptophan biosynthesis and metabolism, with significantly altered metabolites labeled in red (GF>CONV-R) or blue (GF<CONV-R) (two-sided Welch’s t -test, fold change ≥ 1.5, p < 0.01). c, d Box and Whisker plots of fecal indoles ( c ) and bile acid profiles ( d ) as synthesized or mediated by microbiota, with the box ranging from the first quartile to the third while the whiskers going from each quartile to the minimum or maximum (GF, N = 12; CONV-R, N = 12), * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001, two-sided Welch’s t -test; exact p values and adjusted p values (i.e., q values) are provided in Supplementary Data . SM sphingomyelin, Phe L-phenylalanine, Tyr L-tyrosine, Trp L-tryptophan, 5-HT 5-hydroxytryptamine, NAS N-acetylserotonin, 5-MIAA 5-methoxyindole-3-acetate, Kyna kynurenate, Kyn L-kynurenine, AA anthranilate, XA xanthurenate, IAA <t>indole-3-acetate,</t> IPA indole-3-propionate, ILA indole-3-lactate, I3A indole-3-carboxaldehyde, L-DOPA L-3,4-dihydroxyphenylalanine, DHICA 5,6-dihydroxyindole-2-carboxylate, CDCA chenodeoxycholate, CA cholate, αMCA α-muricholate, TCDCA taurochenodeoxycholate, TCA taurocholate, TαMCA tauro α-muricholate, DCA deoxycholate, HDCA hyodeoxycholate, LCA lithocholate.
Labeled Internal Standard Indole 3 Propionic 2,2 D 2 Acid No. D 7686, supplied by CDN Isotopes, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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A – C The expression of Asct2 and Gls1 at the mRNA and protein level on day 1, 3, and 5 during OC differentiation. Statistical significance: * p < 0.05, ** p < 0.01, *** p < 0.001; ns, no significance. D , E Glu regulate RANKL-induced osteoclastogenesis in a concentration-dependent manner. BMDMs were treated with different concentrations of Glu (0 mM,0.5 mM, 1 mM, 2 mM and 4 mM) or 5 μM V9302 for 5 days. TRAP-positive multinucleated (>3 nuclei) cells were counted as osteoclasts. * p < 0.05, ** p < 0.01, *** p < 0.001. F , G BMDMs were seeded on 0.2% collagen-gel-coated 6-well plates and stimulated with 30 ng/ml M- CSF and 75 ng/ml RANKL for 6 days. Then, the cells were digested and seeded onto the Osteo Assay stripwell plates. Mature osteoclasts were treated with various concentrations of Glu or 5 μM V9302 for 5 days. F-actin staining was then performed. * p < 0.05, ** p < 0.01, *** p < 0.001. H , I Pit formation assay in the Glu (0 mM,0.5 mM, 1 mM, 2 mM and 4 mM) or 5 μM V9302 treated group. Mature osteoclasts were cultured on Osteo Assay stripwell plates and treated with the medium containing RANKL and various concentrations of Glu for 2 days. The cells were then washed from the surface by using the 10% bleaching solution for 5 min. Resorption pits were captured with light microscopy and analyzed with Image J software. * p < 0.05, ** p < 0.01, *** p < 0.001. J – M BMDMs were cultured with the medium containing M- CSF, RANKL and various concentrations of Glu or were treated by 5 μM V9302 for 5 days. Relative mRNA expression levels of Nfatc1, Mmp9, Ctsk, and Acp5 versus β-Actin were quantified by qPCR. *compared to Glu (0 mM)/V9302 (0 μM) group; #compare to Glu (2 mM)/V9302(0 μM) group; * p < 0.05, ** p < 0.01, *** p < 0.001. # p < 0.05, ## p < 0.01, ### p < 0.001.

Journal: Cell Death & Disease

Article Title: IL-17 promotes osteoclast-induced bone loss by regulating glutamine-dependent energy metabolism

doi: 10.1038/s41419-024-06475-2

Figure Lengend Snippet: A – C The expression of Asct2 and Gls1 at the mRNA and protein level on day 1, 3, and 5 during OC differentiation. Statistical significance: * p < 0.05, ** p < 0.01, *** p < 0.001; ns, no significance. D , E Glu regulate RANKL-induced osteoclastogenesis in a concentration-dependent manner. BMDMs were treated with different concentrations of Glu (0 mM,0.5 mM, 1 mM, 2 mM and 4 mM) or 5 μM V9302 for 5 days. TRAP-positive multinucleated (>3 nuclei) cells were counted as osteoclasts. * p < 0.05, ** p < 0.01, *** p < 0.001. F , G BMDMs were seeded on 0.2% collagen-gel-coated 6-well plates and stimulated with 30 ng/ml M- CSF and 75 ng/ml RANKL for 6 days. Then, the cells were digested and seeded onto the Osteo Assay stripwell plates. Mature osteoclasts were treated with various concentrations of Glu or 5 μM V9302 for 5 days. F-actin staining was then performed. * p < 0.05, ** p < 0.01, *** p < 0.001. H , I Pit formation assay in the Glu (0 mM,0.5 mM, 1 mM, 2 mM and 4 mM) or 5 μM V9302 treated group. Mature osteoclasts were cultured on Osteo Assay stripwell plates and treated with the medium containing RANKL and various concentrations of Glu for 2 days. The cells were then washed from the surface by using the 10% bleaching solution for 5 min. Resorption pits were captured with light microscopy and analyzed with Image J software. * p < 0.05, ** p < 0.01, *** p < 0.001. J – M BMDMs were cultured with the medium containing M- CSF, RANKL and various concentrations of Glu or were treated by 5 μM V9302 for 5 days. Relative mRNA expression levels of Nfatc1, Mmp9, Ctsk, and Acp5 versus β-Actin were quantified by qPCR. *compared to Glu (0 mM)/V9302 (0 μM) group; #compare to Glu (2 mM)/V9302(0 μM) group; * p < 0.05, ** p < 0.01, *** p < 0.001. # p < 0.05, ## p < 0.01, ### p < 0.001.

Article Snippet: V9302 was purchased from MedChemExpress (HY-W015229, MedChemExpress, USA).

Techniques: Expressing, Concentration Assay, Staining, Tube Formation Assay, Cell Culture, Light Microscopy, Software

BMDMs were cultured with the medium that containing M-CSF (30 ng/ml) and RANKL (75 ng/mL) for 5 days with or without Glu deprivation, as well as treated with indicated stimulation, including IL-17(0.1 ng/ml), V9302 (5 μM) and α-KG (0.5 mM). A , B BMDMs were seeded in Seahorse XF analyzer culture plates and treated as described. Extracellular acidification rate (ECAR) was analyzed by XF Cell Mito Stress Assay. C , D BMDMs were seeded in Seahorse XFp analyzer culture plates and treated as described. Oxygen consumption rate (OCR) were analyzed by XF Cell Mito Stress Assay. E BMDMs were seeded in 6 well plates and treated as described. The levels of lactate were analyzed through Lactate Assay kit. F , G BMDMs were cultured with the Glu deprived medium that containing M-CSF (30 ng/ml) and RANKL (75 ng/mL) for 5 days, as well as treated with or without IL-17 (0.1 ng/ml) and α-KG (0.5 mM). TRAP-positive multinucleated (>3 nuclei) cells were counted as osteoclasts. H , I QPCR and Western blot assay examining the the expression of gene of osteoclast marker and IL-17 signaling pathway. * p < 0.05, ** p < 0.01, *** p < 0.001; ns, no significance.

Journal: Cell Death & Disease

Article Title: IL-17 promotes osteoclast-induced bone loss by regulating glutamine-dependent energy metabolism

doi: 10.1038/s41419-024-06475-2

Figure Lengend Snippet: BMDMs were cultured with the medium that containing M-CSF (30 ng/ml) and RANKL (75 ng/mL) for 5 days with or without Glu deprivation, as well as treated with indicated stimulation, including IL-17(0.1 ng/ml), V9302 (5 μM) and α-KG (0.5 mM). A , B BMDMs were seeded in Seahorse XF analyzer culture plates and treated as described. Extracellular acidification rate (ECAR) was analyzed by XF Cell Mito Stress Assay. C , D BMDMs were seeded in Seahorse XFp analyzer culture plates and treated as described. Oxygen consumption rate (OCR) were analyzed by XF Cell Mito Stress Assay. E BMDMs were seeded in 6 well plates and treated as described. The levels of lactate were analyzed through Lactate Assay kit. F , G BMDMs were cultured with the Glu deprived medium that containing M-CSF (30 ng/ml) and RANKL (75 ng/mL) for 5 days, as well as treated with or without IL-17 (0.1 ng/ml) and α-KG (0.5 mM). TRAP-positive multinucleated (>3 nuclei) cells were counted as osteoclasts. H , I QPCR and Western blot assay examining the the expression of gene of osteoclast marker and IL-17 signaling pathway. * p < 0.05, ** p < 0.01, *** p < 0.001; ns, no significance.

Article Snippet: V9302 was purchased from MedChemExpress (HY-W015229, MedChemExpress, USA).

Techniques: Cell Culture, Lactate Assay, Western Blot, Expressing, Marker

a Variable importance plot of top 50 fecal metabolites ( y -axis) ranked by contribution to mean decrease accuracy of Gini coefficient ( x -axis) in the random forest model for discerning group difference. b Diagram summary of perturbed fecal pathways of phenylalanine, tyrosine, and tryptophan biosynthesis and metabolism, with significantly altered metabolites labeled in red (GF>CONV-R) or blue (GF<CONV-R) (two-sided Welch’s t -test, fold change ≥ 1.5, p < 0.01). c, d Box and Whisker plots of fecal indoles ( c ) and bile acid profiles ( d ) as synthesized or mediated by microbiota, with the box ranging from the first quartile to the third while the whiskers going from each quartile to the minimum or maximum (GF, N = 12; CONV-R, N = 12), * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001, two-sided Welch’s t -test; exact p values and adjusted p values (i.e., q values) are provided in Supplementary Data . SM sphingomyelin, Phe L-phenylalanine, Tyr L-tyrosine, Trp L-tryptophan, 5-HT 5-hydroxytryptamine, NAS N-acetylserotonin, 5-MIAA 5-methoxyindole-3-acetate, Kyna kynurenate, Kyn L-kynurenine, AA anthranilate, XA xanthurenate, IAA indole-3-acetate, IPA indole-3-propionate, ILA indole-3-lactate, I3A indole-3-carboxaldehyde, L-DOPA L-3,4-dihydroxyphenylalanine, DHICA 5,6-dihydroxyindole-2-carboxylate, CDCA chenodeoxycholate, CA cholate, αMCA α-muricholate, TCDCA taurochenodeoxycholate, TCA taurocholate, TαMCA tauro α-muricholate, DCA deoxycholate, HDCA hyodeoxycholate, LCA lithocholate.

Journal: Nature Communications

Article Title: High-coverage metabolomics uncovers microbiota-driven biochemical landscape of interorgan transport and gut-brain communication in mice

doi: 10.1038/s41467-021-26209-8

Figure Lengend Snippet: a Variable importance plot of top 50 fecal metabolites ( y -axis) ranked by contribution to mean decrease accuracy of Gini coefficient ( x -axis) in the random forest model for discerning group difference. b Diagram summary of perturbed fecal pathways of phenylalanine, tyrosine, and tryptophan biosynthesis and metabolism, with significantly altered metabolites labeled in red (GF>CONV-R) or blue (GF

Article Snippet: Stable-isotope-labeling internal standards for a range of classical neurotransmitters and tryptophan catabolites, including acetylcholine-d13 (N,N,N-trimethyl-d9; 1,1,2,2-d4) (d13-ACh; catalog #D-1780), γ-aminobutyric acid-d2 (d2-GABA; catalog #D-1731), L-glutamine-2,3,3,4,4-d5 (d5-Gln; catalog #D-2532), L-tryptophan-2,3,3-d3 (d3-Trp; catalog #D-7419), serotonin-α,α,β,β-d4 (d4-5HT; catalog #D-1550), L-kynurenine (ring-d4, 3,3-d2) (d6-Kyn; catalog #DLM-7842), indole-3-acetic-2,2-d2 acid (d2-IAA; catalog #D-1709) and indole-3-propionic-2,2-d2 acid (d2-IPA; catalog #D-7686) were obtained from CDN Isotopes (Pointe-Claire, Quebec, Canada) and Cambridge Isotopes (Tewksbury, MA, USA).

Techniques: Labeling, Whisker Assay, Synthesized

a Variable importance plot of top 50 serum metabolites ( y -axis) ranked by contribution to mean decrease accuracy of Gini coefficient ( x -axis) in the random forest model for discerning group difference. b Diagram summary of perturbed serum pathways of phenylalanine, tyrosine and tryptophan biosynthesis and metabolism. c, d MetaMapp metabolomic networks of 88 metabolite pairs altered in feces ( c ) and serum ( d ), with nodes representing individual metabolites, edges for biochemical (KEGG reactant pairs) and chemical (Tanimoto coefficient > 0.7) relationships, and lower transparency for lower adjusted p values (<0.05, two-sided Welch’s t -test). TMAO trimethylamine N-oxide, PS phosphatidylserine, Phe L-phenylalanine, Tyr L-tyrosine, Trp L-tryptophan, Kyn L-kynurenine, AA anthranilate, IAA indole-3-acetate, IPA indole-3-propionate, ILA indole-3-lactate, IArcA indole-3-acrylate, I3A indole-3-carboxaldehyde, Shikimate 3-P shikimate 3-phosphate, DHICA 5,6-dihydroxyindole-2-carboxylate, AKG α-ketoglutarate, L-DOPA L-3,4-dihydroxyphenylalanine, SULT sulfotransferase, CYP450 cytochrome 450, TCA cycle tricarboxylic acid cycle.

Journal: Nature Communications

Article Title: High-coverage metabolomics uncovers microbiota-driven biochemical landscape of interorgan transport and gut-brain communication in mice

doi: 10.1038/s41467-021-26209-8

Figure Lengend Snippet: a Variable importance plot of top 50 serum metabolites ( y -axis) ranked by contribution to mean decrease accuracy of Gini coefficient ( x -axis) in the random forest model for discerning group difference. b Diagram summary of perturbed serum pathways of phenylalanine, tyrosine and tryptophan biosynthesis and metabolism. c, d MetaMapp metabolomic networks of 88 metabolite pairs altered in feces ( c ) and serum ( d ), with nodes representing individual metabolites, edges for biochemical (KEGG reactant pairs) and chemical (Tanimoto coefficient > 0.7) relationships, and lower transparency for lower adjusted p values (<0.05, two-sided Welch’s t -test). TMAO trimethylamine N-oxide, PS phosphatidylserine, Phe L-phenylalanine, Tyr L-tyrosine, Trp L-tryptophan, Kyn L-kynurenine, AA anthranilate, IAA indole-3-acetate, IPA indole-3-propionate, ILA indole-3-lactate, IArcA indole-3-acrylate, I3A indole-3-carboxaldehyde, Shikimate 3-P shikimate 3-phosphate, DHICA 5,6-dihydroxyindole-2-carboxylate, AKG α-ketoglutarate, L-DOPA L-3,4-dihydroxyphenylalanine, SULT sulfotransferase, CYP450 cytochrome 450, TCA cycle tricarboxylic acid cycle.

Article Snippet: Stable-isotope-labeling internal standards for a range of classical neurotransmitters and tryptophan catabolites, including acetylcholine-d13 (N,N,N-trimethyl-d9; 1,1,2,2-d4) (d13-ACh; catalog #D-1780), γ-aminobutyric acid-d2 (d2-GABA; catalog #D-1731), L-glutamine-2,3,3,4,4-d5 (d5-Gln; catalog #D-2532), L-tryptophan-2,3,3-d3 (d3-Trp; catalog #D-7419), serotonin-α,α,β,β-d4 (d4-5HT; catalog #D-1550), L-kynurenine (ring-d4, 3,3-d2) (d6-Kyn; catalog #DLM-7842), indole-3-acetic-2,2-d2 acid (d2-IAA; catalog #D-1709) and indole-3-propionic-2,2-d2 acid (d2-IPA; catalog #D-7686) were obtained from CDN Isotopes (Pointe-Claire, Quebec, Canada) and Cambridge Isotopes (Tewksbury, MA, USA).

Techniques: